A leave of absence was a period of varying duration in which a member of Starfleet was off duty and not assigned to any posting. The leave of absence had to be granted by a superior officer, who also had authority to recall one into active service.

In 2151, Hoshi Sato had a leave of absence to teach at Amazon University, which she ended prematurely to serve aboard Enterprise NX-01. (ENT: "Broken Bow")

In 2152, Jonathan Archer offered T'Pol a leave of absence after her second encounter with Menos triggered traumatic memories, but she considered it unnecessary. (ENT: "The Seventh")

After the end of the Federation-Klingon war of 2256-57, Lieutenant Spock requested leave after the appearance of red bursts throughout the galaxy. Captain Christopher Pike agreed to the request, noting that Spock had months of leave time accumulated. (DIS: "Brother")

In 2267, Spock requested a leave of absence from the USS Enterprise to visit Vulcan due to his pon farr. (TOS: "Amok Time")

In 2366, Worf asked for a leave of absence from the USS Enterprise-D in order to travel to Qo'noS and hear the charges against his father, who had been accused of aiding and abetting an attack on a Romulan outpost. Captain Jean-Luc Picard refused, saying instead that he would come with him, as it was only right that he by his side as his captain, since his actions would reflect on the ship and the Federation. (TNG: "Sins of the Father")

That same year, Lwaxana Troi asked her daughter whether she had ever thought about a leave of absence. (TNG: "Ménage à Troi")

In 2367, Worf was granted a leave of absence from the Enterprise-D by Jean-Luc Picard to participate in events surrounding Gowron's inauguration. After the Klingon Civil War had started, Worf asked Picard for an extended leave of absence, but was refused; Worf then resigned his commission. (TNG: "Redemption")

In 2369, Deanna Troi recommended a leave of absence to Reginald Barclay and temporarily relieved him of duty. (TNG: "Realm of Fear")

In 2370, Jadzia Dax requested a leave of absence from Deep Space 9 to chase The Albino. Benjamin Sisko initially refused this request, but Dax eventually convinced him. (DS9: "Blood Oath")

The following year, Dax requested another leave of absence to live on Meridian, this time for sixty years. (DS9: "Meridian")

In 2373, Odo assured Arissa he would protect her even if he'd have to take a leave of absence. (DS9: "A Simple Investigation")

In 2374, following the First Battle of Chin'toka, Sisko took a leave of absence to live on Earth. (DS9: "Tears of the Prophets")

Following her joining with the Dax symbiont in 2375, Ezri Dax took a leave of absence from the USS Destiny to visit Sisko on Earth. (DS9: "Shadows and Symbols")

In 2376, Deanna Troi asked Picard for a temporary leave of absence from the USS Enterprise-E to again help Barclay on Earth. (VOY: "Pathfinder")

In 2377, The Doctor asked for a temporary leave of absence from the USS Voyager to attend a symposium in the Ovion system. The request was denied by Chakotay. (VOY: "Flesh and Blood")

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