The Liu Region was a region on the planet Acamar III.
In 2313, the Gatherer leader Penthor-Mul requested a change of venue for his trial proceedings from Vackrinos District, the location of his botched raid on an outpost, to this region. The request was denied by Judge Kikimor.
In 2366, this region was mentioned in the court records of Penthor-Mul, which were accessible to the crew of the USS Enterprise-D via the Acamarian planetary database. (TNG: "The Vengeance Factor", okudagram)
This region was only mentioned in writing.