Louise was a young woman from a planet originally almost identical to 1960s Earth. Like all survivors on her world, Louise was infected with a virus. When the USS Enterprise landing party encountered her in 2266, she was over three hundred years old.
That same year, she entered puberty, and was completely transformed by the infection. Her fellow children ran from her screaming, then she attacked Captain James T. Kirk. She died after Kirk shot her with a phaser set on stun. Louise had been only a little bit older than Miri was at the time of her death. (TOS: "Miri")