Lysian destroyers employed disruptor-style weapons, that had a capacity of 2.1 megajoules, and were protected by minimal shields. These warships were "greatly outclassed" by the Federation's Galaxy-class starships, as their level of weapons technology was "over 100 years behind" that which was employed by the Federation during the 2360s.
In 2368, the USS Enterprise-D encountered and destroyed a Lysian destroyer after being tricked by a Satarran ploy that intentionally brought the ship and the Federation into the war between the two powers. After making contact with the Lysians, Enterprise Captain Jean-Luc Picard conveyed the Federation's "deepest regrets over the tragedy of their lost ship and crew." (TNG: "Conundrum")