Mab-Bu VI was the sixth planet in its star system. This gas giant planet with an M-class moon was located in the same sector as Starbase 12. (TNG: "Power Play")
According to Star Trek: Star Charts (p. 47) and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), the Mab-Bu system was located in the Alpha Quadrant. The system's primary was a M-class star. In the late 24th century, it was an independent system.
According to the Star Trek Encyclopedia (3rd ed., p. 281), Mab-Bu VI was located in Federation space.
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