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Memory Alpha
Multiple realities
(covers information from several alternate timelines)

The main shuttlebay of the Enterprise-D

The main shuttlebay, also known as the main bay or Shuttlebay 01, was the largest of three shuttlebay facilities aboard Galaxy-class starships, located across Decks 3 and 4 of the saucer section. The shuttlebay was enormous and accessed by one roll-up door. Decompressing the main shuttlebay would provide enough thrust to move the entire ship. (TNG: "Cause and Effect") It was also sufficiently large enough to house three Danube-class runabouts. (DS9: "Emissary")

Jake Kurland stole a shuttle from the main shuttlebay of the USS Enterprise-D in 2364, intending to fly it to Beltane IX and join the crew of a freighter. (TNG: "Coming of Age")

In early 2366, the Type 7 shuttlecraft Sakharov, Tereshkova, and McAuliffe, along with the Type 15 shuttlepods Lindberg, Cochrane, Curie, and Feynman, were listed on the shuttlebay operations display as being in the main bay. (TNG: "Evolution", okudagram)

The shuttlepod Ley, after traveling through the Barzan wormhole, returned to the Enterprise through the main shuttlebay. (TNG: "The Price")

Q stole the Sakharov from the main shuttlebay of the Enterprise-D, intending to sacrifice himself to the Calamarain and save the Enterprise-D. (TNG: "Deja Q")

In an alternate timeline 2366, aboard the Enterprise-D, triage team 2 was ordered to the main shuttlebay. (TNG: "Yesterday's Enterprise")

Worf and Data departed the separated Enterprise saucer from the main shuttlebay, while the saucer was distracting the Borg with an antimatter spread. This provided cover for the shuttle to penetrate the Borg cube's electromagnetic field and rescue Captain Jean-Luc Picard, assimilated as Locutus of Borg. (TNG: "The Best of Both Worlds, Part II")

A graphic of the Nenebek leaving the main shuttlebay

The Nenebek in a shuttlebay

The Nenebek left the Enterprise through its main shuttlebay. (TNG: "Final Mission")

It was seen on a viewscreen (verified by text and a graphic) that the Nenebek left the ship through the main shuttlebay. In a previous shot that showed the passengers enter the shuttle seconds before departure, the Nenebek is seen in the shuttlebay, but the regular small shuttlebay set is seen, albeit darkly lit. No large yellow number is seen of the floor that normally would indicate shuttlebay 2 or 3, so the Nenebek was either kept in an adjacent room or we do see part of the main shuttlebay in "Final Mission".

Prior to its contact with the Cytherian probe, the Feynman departed from this bay. (TNG: "The Nth Degree")

In 2368, Doctor Beverly Crusher ordered all three Enterprise shuttlebays, including the main shuttlebay, be converted for emergency triage operations in preparation for the rescue of USS Denver survivors. (TNG: "Ethics")

Later that year, the Enterprise main shuttlebay housed the Type 6 shuttlecraft Berman and Piller. The shuttles were present when the main shuttlebay was decompressed to avoid a collision with the USS Bozeman, freeing both ships from a temporal causality loop. (TNG: "Cause and Effect")

Background information

The main shuttlebay model

Due to its size, the main shuttlebay would have been prohibitively expensive to construct as a full-sized set. It was only seen twice during the run of TNG as a wall through the window of a shuttle during "The Best of Both Worlds, Part II" (a simple reuse of the existing shuttle/cargo bay set), and as a partial miniature built by Ed Miarecki for "Cause and Effect". [1]

The Sovereign-class USS Enterprise-E also has a shuttlebay in a similar location on its saucer section, used in both Star Trek: Insurrection and Star Trek Nemesis. Unlike the Enterprise-D, it featured segmented doors as opposed to one large door, and was not identified as the main shuttlebay in dialogue.