(written from a Production point of view)
This page contains information regarding Star Trek: Discovery, and thus may contain spoilers.
Chieffo watched previous series with Klingon episodes and commented: "[The series that] that keeps coming up when we're talking about serialized Star Trek is Deep Space Nine, because those last three seasons really do start to have a new, serialized quality. Somebody on Twitter yesterday said, "Has she watched Deep Space Nine?" Or something like that. I was like, "Yeah, actually. In those last three seasons, I got so caught up in the plot that I stopped just watching the Klingon-featured episodes, because I felt that it became extremely profound." I think it's got so much nuance, and all the characters are so wonderful, and lovable, and the way that they really get to evolve and develop is wonderful. Of course, I have a soft spot for Odo. Then, I think about the great female Klingons on the show, and one of my favorites, Grilka, comes in". 
The daughter of actors Michael Chieffo and Beth Grant, Chieffo appeared as a sleeping baby in the short Making Sandwiches (1998) directed by Sandra Bullock. She graduated from high school in 2011, being the valedictorian of her graduating class. She then attended the Drama Division of Juilliard School (bearing the nickname "Valedictorian"), where she was in the same class as Mary Wiseman and graduated with a BFA in 2015. 
She appeared in a theater production of Othello and also in movies like Natural Disasters (2008), Herpes Boy (2009), Girls! Girls! Girls! (2011), Miss Dial (2013), and Shelby's Vacation (2017). She also appeared in the short movies Odyssea (2013) and The Perfect Fit (2012) and the unaired TV movie Jack and Janet Save the Planet (2009).
In 2017, she appeared in an episode of The Mindy Project.
Chieffo is describing herself as a Shakespeare Lover, Feminist and Geek.