Mayweather may refer to:
- Travis Mayweather, primary watch helmsman aboard the Enterprise (NX-01)
- Captain Mayweather, father to Travis and Paul Mayweather
- Rianna Mayweather, wife of Captain Mayweather, and mother to Travis and Paul
- Paul Mayweather, brother of Travis Mayweather, and captain of the ECS Horizon after his father's death
- Mayweather's sister 001, sister to Travis and Paul Mayweather
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