The Enterprise-D approaches the McAllister C-5-Nebula

The McAllister C-5 Nebula was a protostellar nebula located inside Cardassian space in Sector 71527, approximately seven light years from the Federation border and eleven light years from the Federation system Minos Korva. The particle flux inside the McAllister Nebula prevented starships from staying inside it for more than 72 hours.

In 2369, the McAllister Nebula was used by Cardassian forces to hide their ships in order to begin a sneak attack on Minos Korva. However, this plan was blighted by Captain Edward Jellico, who commanded the USS Enterprise-D on a temporary assignment and detected the Cardassian ships inside the nebula. (TNG: "Chain of Command, Part II")

According to Star Trek: Star Charts (p.47) and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), the McAllister C-5 Nebula was located in the Alpha Quadrant.
In the Star Trek Online timeline, the USS Enterprise-E visited the nebula to conduct research in the year 2390. During their study, scans revealed quantum singularities which hinted at the presence of Species 8472 in the area.

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