In 2368, the USS Enterprise-D delivered Federation colonists and supplies to the planet. Several Enterprise-D crewmembers, including Commander Riker, Doctor Beverly Crusher, and Lieutenant Commander Data, assisted in establishing the Melona colony.
Later that year, Melona IV was stripped of all life by the Crystalline Entity, which also claimed the lives of two colonists, one of them being civilian engineer Carmen Davila. The remainder of the colonists and the Enterprise-D personnel managed to survive by hiding in nearby caves rich with kelbonite and fistrium. (TNG: "Silicon Avatar")
According to the script, the pronunciation for Melona was "mel-OWN-uh". The planet is described, prior to its destruction, as being "a lush and verdant world of hills, grasses, and wild flowers".