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The Metreon Cascade was a weapon designed by Dr. Ma'bor Jetrel of the Haakonian Order. It used unstable Metreon isotopes to create a devastating explosion. The resulting radioactive poisoning killed those who were not wiped out in the initial blast. Sufficient exposure to Metreons resulted in the disease Metremia.

The Cascade was only used once, on the Talaxian moon of Rinax in 2355. (VOY: "Jetrel")

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