Midos V was the inhabited fifth planet of its star system. This planet was rich in raw materials and the location of a small Earth colony. It was also one of the USS Enterprise's scheduled stops in 2266.

That same year, Roger Korby enlisted an android duplicate of James T. Kirk to arrange him transportation off Exo III to a nearby planet colony with proper raw materials to begin producing androids. Korby noted that there were several good possibilities among the USS Enterprise's next stops without diverting from the ship's route, as he didn't want to arouse suspicions. In response, the android Kirk chose Midos V, noting that it was "an excellent choice" for Korby's needs. (TOS: "What Are Little Girls Made Of?")

In 2328, this planet was home for the Midos V Satellite City Spaceport. (TNG-R: "Inheritance")

Originally, this planet was named "Minos III" (evidenced by a series of research notes that Kellam de Forest issued on 11 May 1966). The planet was subsequently renamed "Minos V" (evidenced by another set of de Forest's research notes, submitted on 27 July 1966).
According to Star Trek: Star Charts ("United Federation of Planets I"), in 2378, Midos V was listed as a Federation member.