Multiple realities
(covers information from several alternate timelines)
The Mission District referred to an area of San Francisco, California. One of the Trans Francisco public transit system's subway lines ran through the district. (VOY: "Non Sequitur")
In the 20th century, Mercy Hospital was located in the Mission District. (Star Trek IV: The Voyage Home)
In an alternate timeline version of 2372, the Mission District hosted the Old Town Festival. It contained establishments like Cosimo's and Camillo's, a flower shop, and a vintage book shop. In the same timeline, Harry Kim and Libby moved into an apartment in the district. (VOY: "Non Sequitur")