Missus, abbreviated Mrs., was a title given to a man's wife, following marriage, that was often used as a means to informally identify her without using her given name. In contrast, an unmarried woman would be addressed as "Miss"; whereas, the male equivalent of both titles was "Mister".

This formality was also used by students when addressing their teachers, as was the case with Mrs. Narsu, and Mrs. O'Brien. (TNG: "Masks"; DS9: "Babel", "Move Along Home", "The Nagus", "In the Hands of the Prophets", "The Siege", "Cardassians", "The Jem'Hadar", "The Abandoned")

In the ancient Earth fairy tale Rumpelstiltskin, the namesake character addressed the young Queen, when inquiring whether she knew his name, as "Mrs. Queen". (DS9: "If Wishes Were Horses")

When the Jack London first encountered a time traveling Data, who was wearing an unfamiliar-to-1893 Starfleet uniform and requesting temporary lodging, he replied that it "Looks like the missus booted you out in the middle of the night." Data then responded, as only Data would, "I understand the source of your misperception. However, this is not sleepware and I do not have a missus." (TNG: "Time's Arrow")

When Charles Tucker III was having a discussion with Doctor Phlox about Phlox's visiting wife in 2152, Tucker inadvertently called her by her given name before correcting himself, stating, "Feezal, I mean, Mrs. Phlox..." (ENT: "Stigma")

During the USS Enterprise's visit to planet M-113 in 2266, Robert Crater's wife, Nancy, was addressed by Captain James T. Kirk as "Mrs. Crater". After Crewman Green searched for Nancy, who was at the time missing, Doctor Leonard McCoy, who was previously familiar with Nanacy, asked "Have you seen Nancy..." before correcting himself and saying "Mrs. Crater?" (TOS: "The Man Trap")

Upon meeting Spock's mother Amanda in 2267, Captain Kirk initially addressed her as "Madam", before calling her "Mrs. Sarek," however, she preferred to be called "Amanda," adding "I'm afraid you couldn't pronounce the Vulcan name." Despite her request of using her given name, Kirk and Dr. McCoy continued to refer to her as "Mrs. Sarek". (TOS: "Journey to Babel") A century later, Captain Jean-Luc Picard addressed Sarek's second wife as "Mrs. Sarek" as well, but she insisted, "Please call me Perrin, Captain." (TNG: "Sarek")

During the simulated life experienced by William T. Riker as created by Barash, Riker asked the computer to display the family record for his deceased "wife", Min, by requesting, "Display family record. Riker, Mrs. William T." The same request was also made by his "son", Jean-Luc. (TNG: "Future Imperfect")

During one of many visits aboard the USS Enterprise-D, Ambassador Lwaxana Troi stated to Dr. Timicin, a man with whom she was attracted, after he addressed her as "Mrs. Troi", that "These two [referring to Data and Geordi La Forge] call me Mrs. Troi. You call me Lwaxana." (TNG: "Half a Life")

Shortly after the transfer of Chief Miles O'Brien and his family to Deep Space 9, he was overheard quarreling with his wife, Keiko in Quark's by Quark and Odo. After observing their exchange, Quark looked to Odo and said, "Grapevine says Chief O'Brien and the missus are having problems," leaving Odo to respond, "I'll never understand the humanoid need to couple." (DS9: "A Man Alone")

Women addressed as misses Edit

San Francisco Herald, page 3

Headline referring to Jessica Bradley as "Mrs. Arthur Clinton Bradley"

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