On the probe's first flight, a Malon export vessel, eleventh gradient attempted to steal it so they could locate suitable planets as dumping grounds for antimatter waste. To stop them, the crew of Voyager sent the probe into the atmosphere of a class 6 gas giant. The probe was later retrieved by the newly-constructed Delta Flyer, ahead of a competing salvage team sent by Malon Controller Vrelk. (VOY: "Extreme Risk")
Later in 2375, the crew of Voyager used the multispatial probe to explore a pocket of subspace beyond a subspace sinkhole, where a shuttlecraft carrying Tuvok, Tom Paris and The Doctor had crashed. The probe subsequently served as a transporter relay, allowing them to be rescued. (VOY: "Gravity")
When Voyager and the bounty hunter race known as the Hazari began to think of plans to defeat a smart group known as the Think Tank, Tom Paris suggested they use the probe to scout subspace, where the group's ship was known to hide. However, B'Elanna Torres dismissed it, due to the supposition that it would take weeks to scout the area. (VOY: "Think Tank")
Background Information Edit
In "Brief Candle", a short story in the Distant Shores anthology, it is revealed that One's remains were used to create the multispatial probe, explaining why the crew always went to great lengths to recover it as it was literally irreplaceable.