The Mutara Nebula was an interstellar dust cloud located in the Mutara sector. The nebula contained high levels of static discharge and was comprised largely of ionized gases. The combined effect of this made a starship's sensors highly unreliable and shields inoperable when inside. In March of 2285, the nebula ceased to exist when the Genesis Device detonated.
In 2285, it was the site of the fierce Battle of the Mutara Nebula. The battle ended when Khan Noonien Singh detonated the experimental Genesis Device inside the nebula aboard the USS Reliant, in an attempt to destroy the USS Enterprise. Captain Spock, however, repaired the damaged reactor aboard the Enterprise, allowing the warp drive to function and saving the ship. The detonation caused matter within the nebula to re-form into the Genesis Planet. (Star Trek II: The Wrath of Khan)
Recycled footage of the Mutara Nebula, slightly recolored, was reused as the Mar Oscura Nebula in "In Theory". Later, some visuals of the nebula, turned upside-down and slightly modified, were reused as the Chamra Vortex in "Vortex" and an unnamed Gamma Quadrant nebula in "In Purgatory's Shadow". Visuals of the nebula also appear in modified form in certain shots of the Paulson Nebula in "The Best of Both Worlds".
According to Star Trek: Star Charts ("United Federation of Planets II") and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), the Mutara Nebula was located in the Beta Quadrant.