NCC-500 was the registry number of a Federation Saladin-class destroyer that was in service with Starfleet in the mid-23rd century. (Star Trek II: The Wrath of Khan; Star Trek III: The Search for Spock)

The registry, like the class, was originally derived from the Star Fleet Technical Manual. According to that manual, NCC-500 was named the USS Saladin and was the prototype of the Saladin-class of Federation starships.

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