The galactic barrier, a form of negative energy

Negative energy is an exotic force, whose relationship to normal energy is analogous to the relationship between antimatter and normal matter.

The barrier at the edge of the galaxy was composed of negative energy. In 2268, the Kelvans took over the starship USS Enterprise and set the ship on a course through the barrier. Spock and Montgomery Scott devised a plan whereby they would flood the warp nacelles with positive energy, which would have led to the destruction of the ship when the positive energy came into contact with the negative energy of the barrier. The plan was rejected by Captain Kirk. (TOS: "By Any Other Name")

The space amoeba, encountered by the Enterprise during the same year, was surrounded by a layer of negative energy, which proved to be toxic to humanoid life. (TOS: "The Immunity Syndrome")

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