The soil on Nepenthe possessed regenerative properties, which promoted plant growth and healing. The planet's surface featured vast forests, large rock arches, and pristine bodies of water. Local fauna included Bunnicorns, birds and insects. (PIC: "Nepenthe")
Due to the planet's regenerative powers, William T. Riker and Deanna Troi settled on Nepenthe after their son Thad was diagnosed with mendaxic neurosclerosis. They continued living on the planet after Thad's death.
Pursued by Romulans in 2399, Jean-Luc Picard and Soji Asha used the spatial trajector in the queencell of the Artifact to escape to Nepenthe. Upon their arrival, Picard and Soji met Kestra Troi-Riker, who showed them to her parents' house. A few days later, La Sirena retrieved Picard and Soji from the planet. (PIC: "The Impossible Box", "Nepenthe")