Neuroleptic shock was an adverse nervous system condition caused by certain types of energy. The experience of a neuroleptic shock was quite painful.

In early 2373, Kes suffered a severe neuroleptic shock after inadvertantly entering a Nechisti shrine surrounded by a powerful biogenic field. The shock disrupted her synaptic functions, resulting in a state similar to a coma but without the biochemical markers. After undergoing a Nechisti ritual, Captain Kathryn Janeway was able to heal her by taking her back into the shrine. (VOY: "Sacred Ground")

When the Srivani infiltrated the USS Voyager in 2374, The Doctor believed that he could neutralize their genetic tags on the crew using a neuroleptic shock. Seven of Nine attempted to modify the ship's EPS relays to generate the shock without alerting the Srivani, but was unsuccessful. (VOY: "Scientific Method")

In 2376, Tuvok entered neuroleptic shock after being struck by a Ba'Neth directed energy weapon. The Doctor was able to stabilize him by administering synaptizine, but Tuvok suffered damage to his cognitive, logic, and memory centers. (VOY: "Riddles")

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