Nuclear fusion is a physical reaction that could be harnessed as a form of power generation; it is the very process which causes stars to shine. On Earth, Fusion replaced nuclear fission at the start of the Fusion era

Helium fusion enhancement was at the center of Doctor Timicin's studies to re-vitalize the Kaelon sun. (TNG: "Half a Life")

During the late 2360s, the Romulans began performing experiments with trilithium weapons. This technology, which could be used as a nuclear inhibitor, was capable of stopping fusion within a star. As of 2371, they were unable to stabilize it. However, El-Aurian scientist Doctor Tolian Soran was able to create such a weapon, which he used to create a quantum implosion in the Amargosa star. (Star Trek Generations)

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