The Ophiucus system was an inhabited planetary system in the Alpha Quadrant. Inhabited planets in this system included Ophiucus III and Ophiucus VI.

In 2256, during the first Federation-Klingon War, the USS Discovery routed an attack of this system by Klingon warships. (TOS: "Mudd's Women"; TAS: "Mudd's Passion"; DIS: "Choose Your Pain")

In 2399, the location of Ophiucus was labeled in a star chart that was in Fleet Admiral Kirsten Clancy's office at Starfleet Headquarters. (PIC: "Maps and Legends")

According to Star Trek: Star Charts (pp. 18, 19, & 44) and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), the Ophiucus (36 Ophiuchi) system was in the Ophiucus Sector (Sector 008), which was the eighth sector explored by Earth ships. This Beta Quadrant system was colonized by Earth in the 22nd century and was a destination on the Earth trade routes. In the late 24th century, it was a Federation system.
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