In starship classification, an organic-based vessel was a type of vessel composed of organic material. Species 8472 was one such species who used organic-based vessels, identified by the crew of USS Voyager as bio-ships. (VOY: "Scorpion", "Scorpion, Part II")
As of 2373, the Breen were among other species encountered by Starfleet who used organic-based vessels. (VOY: "Scorpion")