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The parietal lobe or parietal cortex was the part of the brain that was located in the middle of the cerebral hemispheres. It aided in integrating sensory information.

When a Bynar was born, a surgeon removed the child's parietal lobe and replaced it with a synaptic processor. In 2153, Phlox described having observed such an operation to Malcolm Reed, which he regarded as having been "very impressive". (ENT: "Regeneration")

In 2152, Phlox, acting under the influence of radiation from a trinary system, wanted to extract the first twelve millimeters of Travis Mayweather's parietal lobe to determine the cause of Mayweather's supposed ill-health. (ENT: "Singularity")

In 2367, Doctor Beverly Crusher detected increased neural activity localized in Jean-Luc Picard's prefrontal and parietal lobes. This was due to Picard's Humanity reasserting itself after his assimilation by the Borg. (TNG: "The Best of Both Worlds, Part II")

In 2368, Seven of Nine injected three other Borg drones with nanoprobes that created new organic interlink nodes in their left parietal lobes. This resulted a new neural link between them, which persisted even after the three were later freed from the Borg Collective. (VOY: "Survival Instinct")

In 2369, William T. Riker suffered damage to his parietal lobe as a result of the Tilonians attempting to access his long-term memory. (TNG: "Frame of Mind")

In 2370, Crusher found a small structural defect in Picard's parietal lobe that could lead to a number of related neurological disorders and syndromes, including Irumodic syndrome. The defect was so small it required a level-4 neurographic scan to be located. By 2399, the abnormality had become enough of a problem to make Picard fall below Starfleet minimums for a certificate for interstellar service, and no matter the treatment options available, the result was terminal. Picard's doctor, Moritz Benayoun, speculated that he might be experiencing loss of appetite, mood swings or unsettling dreams because of the issue. (TNG: "All Good Things..."; PIC: "Maps and Legends")

In 2371, Julian Bashir recorded in his autopsy on Bareil Antos that the damage to his brain began in the parietal lobe and spread through the rest of the brain in a retrograde manner. (DS9: "Life Support")

Danara Pel's parietal lobe had a bio-neural circuitry implant that supplemented her higher brain functions. In 2372, The Doctor removed approximately one gram of B'Elanna Torres' parietal lobe and grafted it onto Pel's brain. (VOY: "Lifesigns")

In 2373, when the Pah-wraith-possessed Keiko O'Brien fell down from the upper level of the Promenade, she suffered a broken femur and a hairline fracture of the right parietal lobe. (DS9: "The Assignment")

In the original script, Keiko had a fracture of the right parietal bone.

In 2375, Koval found that as an apparent result of Bashir's genetically enhanced parietal cortex, his brain's neurocellular structure was not susceptible to Romulan mind probes. (DS9: "Inter Arma Enim Silent Leges")

In 2377, Iko suffered severe edema in his parietal lobe following a beating from Yediq. (VOY: "Repentance")

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