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A pimple was a small deformity found on a humanoid's skin and was a result of blockage of a pore.

The Klingon equivalent of a pimple was the gorch. (Star Trek: Insurrection)

In 2366, Q contemplated, after being transformed into a Human by the Q Continuum as punishment, on the possiblility of having a pimple. (TNG: "Deja Q")

Lwaxana Troi once said that making young boys reasonable often gave them pimples. (TNG: "Cost of Living")

The Doctor, shortly after his activation, complained in 2371 to Kes in sickbay that every "runny nose, stubbed toe, pimple on a cheek" was his responsibility. (VOY: "Parallax")

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