(written from a Production point of view)
Point Barrow was an Alaskan city mentioned in the first draft script of the Star Trek: Deep Space Nine episode "One Little Ship", which likened the idea of being assigned to escort the wives of Cardassian diplomats on inspection tours of the planet Breen to being ordered to guard a weather observation station at Point Barrow.
Point Barrow was also barely visible, marked as the northernmost point of the United States of America on a political map of the North Pacific region. This map was accessed from the USS Enterprise's library computer by the Talosians in 2254. (TOS: "The Cage")