The Praxillus system was an uninhabited multiple star system in the Alpha or Beta Quadrant, containing the star Beta Praxillus.
In 2293, the location of this system was labeled in a star chart found on the navigation console of the USS Enterprise-B. (Star Trek Generations)
In 2367, after a failed attempt to revitalize the star through helium fusion enhancement, Beta Praxillus novaed. (TNG: "Half a Life")