In 2371 Renhol welcomed Dax back. Unfortunately, Jadzia's homecoming was due to an undiagnosed medical condition that threatened the Dax symbiont. Renhol initially prescribed injections meant to increase Jadzia's isoboramine levels. When this approach failed to halt the threat to the symbiont, Renhol wanted to remove Dax and join it with another host, knowing that this procedure would kill Jadzia.
Renhol's decision was not based on the medical needs of the case, however, but on her willingness to keep secret the fact that symbionts could be joined to a much wider segment of the population than was generally known. The symbiont was experiencing flashbacks as the result of the failure of a memory block, a block which the Commission had created in order to cover up the fact that the symbiont had at one time been joined with an unsuitable host, Joran Belar. Benjamin Sisko and Julian Bashir discovered Renhol's motives and threatened to expose the Commission's secret if everything possible was not done to save Jadzia.