Replicator safety protocols were computer sub-systems of food synthesizers which ensured that only safe food was synthesized.
The announcer for a commercial for Tribbles cereal encouraged children to override the replicator safety protocols "and set it for Tribbles!" (ST: "The Trouble with Edward", credit cookie)
The commercial was presented as a post-credits scene in "The Trouble with Edward". The context of the commercial from an in-universe perspective is impossible to determine, and may not have been meant to be taken literally.