A road was a thoroughfare built to allow for ease of travel. A public road was generally called a street. There were also many other types of roads, such as, alleys, avenues, boardwalks, boulevards, drives, freeways, highways, interstates, off-ramps, railroads and tubes.
In 2256, when Michael Burnham asks Captain Gabriel Lorca how a starship could travel on spores, he tells her to imagine a microscopic web that spans the entire cosmos that functions as an intergalactic ecosystem with infinite roads leading everywhere. (DIS: "Context Is for Kings")
Following the revelation of the truth behind the Great Balance in 2257, Commander Saru asked his sister Siranna to come with him on the USS Discovery, but she told him she should remain behind with her people, telling him "there's a long road ahead." (DIS: "The Sound of Thunder")
When former therapist Admiral Cornwell was giving a recently resurrected Doctor Culber some healthy advise about his love-life, she told him "the only way to make a new road is to walk it." (DIS: "The Red Angel")
In 2372, when Lieutenant B'Elanna Torres told Automated Unit 3947 that she didn't think she could make a power module that would allow the Automated Personnel Units to procreate; 3947 told her she had failed. She then asked him "Hey, do all you automated units give up the minute you hit a bump in the road?" (VOY: "Prototype")
In 2376, on the holodeck on Voyager, when Michael Sullivan met Kathryn Janeway at a pub in Fair Haven, Kathryn told him she was just passing through town, and he asked her how long she had been on the road. (VOY: "Fair Haven")
Chakotay once recited to Captain Kathryn Janeway a line from Dante's Inferno, and how he agreed with it, telling her that if you always see the road ahead of you, it is not always worth the trip. (VOY: "Shattered")