From 2361 to 2364, his first officer was Lieutenant Commander William Riker. During a mission to Altair III, Riker refused to allow Captain DeSoto to lead the away mission, due to the dangers the planet possessed. Captain DeSoto had a great respect for Riker and regretted his transfer to the Enterprise-D. (TNG: "Encounter at Farpoint")
DeSoto still commanded the Hood in 2366 when his vessel rendezvoused with the Enterprise-D. DeSoto noted that while the "Galaxy class boys" aboard Enterprise got to enjoy the frontier; "Me, I'm hauling my butt back and forth between starbases". (TNG: "Tin Man")
- Captain DeSoto was played by Michael Cavanaugh.