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A secondary infection was a term used to describe an infection enabled by a weakened immune system that had already been compromised by a prior infection.

In 2369, Doctor Julian Bashir administered corophizine to lower the chances of Chief Miles O'Brien acquiring a secondary infection other than the aphasia virus. (DS9: "Babel")

In 2377, Tebbis died due to a secondary infection of acute chromoviral disease after his medication allotments had been used up. (VOY: "Critical Care")

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