Sector 2158 was a sector of space in the Beta Quadrant.

Many planets in this sector contain archaeological sites of the Debrune or the ancient Romulans, including Barradas III, Calder II, Draken IV, Yadalla Prime, Zoraster II, and Yridia I, as well as several planets in the Taugan system. All those sites except for Draken IV and Yadalla Prime were raided by a mercenary ship commanded by Arctus Baran in 2370. (TNG: "Gambit, Part I")

According to Star Trek: Star Charts (p. 45), based on the locations of the star systems named, this sector was located in the Beta Quadrant.
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