Sector 63 was a region of space. This sector was located in a quadrant that was adjacent to a quadrant, which contained the planet Dytallix B.

In 2364, the starships USS Horatio, USS Renegade, USS Thomas Paine, and USS Enterprise-D rendezvoused at Dytallix B. Shortly after the ships departed, the Enterprise-D picked up an unusual disturbance in this sector. The disturbance was caused by the destruction of the Horatio. (TNG: "Conspiracy")