Serpent might refer to:
- Aldebaran serpent, a three-headed snake-like creature from the Aldebaran system
- Serpent of Xol, creature from Klingon legends
- Serpent women, otherwise known as female U'tani
- Serpent's Ridge, a location on Bajor
- Serpent worm, an animal eaten by Klingons
- Snake, an alternate term for serpent
- Real world
- "How Sharper Than a Serpent's Tooth", the second season Animated Series episode
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