Setlik II was the inhabited second planet in the Setlik system, located near the Federation-Cardassian border in the Alpha Quadrant. It was orbited by a habitable "Ice moon". The planet was the site of a Federation colony, which had been in place for generations by the mid-23rd century.
In 2259, the USS Enterprise was assigned to transport tritriticale grain, which had been specially made to grow in Setlik II's biome, to the colony. En route, they encountered a time travel incident at the portal on Krulmuth-B, and were subsequently forced to trade the tritriticale to the Orion science vessel D'Var to retrieve the portal from them. It was believed that without the grain, the Enterprise would have to relocate the colonists. (SNW: "Those Old Scientists")