Shalaft's Syndrome was a very rare Human illness in which the sufferer developed a hypersensitivity to sound, to the point where even a whisper could cause agony. Genetic (Y linked) in nature, it was passed down to every male in the family.
Jean-Luc Picard suffered from an aggressive strain of Shalaft's Syndrome, as did his clone, Shinzon, when he was very young. Eventually, Shinzon was taken to a doctor with experience in Human illnesses, and he was treated. Shinzon related this story to Captain Picard in 2379, when introducing himself to his counterpart. (Star Trek Nemesis)