The crews of the USS Defiant and later the USS Enterprise experienced a type of space madness after their exposure to the spatial interphase in 2269. Doctor Leonard McCoy described the "madness" as being caused by "the area of space we're in," and that "the molecular structure of the brain tissues in the central nervous system are distorting." (TOS: "The Tholian Web")
Star Trek Timeline [INTERACTIVE]
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