The spleen was an organ of the body that acted primarily as a blood filter.

Strain on the spleen and liver was one of the side-effects of an experimental chemical stimulant designed to speed up reproduction and replacement of blood used in the mid-2260s. While discussing Ambassador Sarek's condition with the Vulcan's wife and son, McCoy mentioned the drug to them, saying that it would likely kill Sarek were it administered in his current condition. (TOS: "Journey to Babel")

In 2268, Leonard McCoy suffered hemorrhage of the spleen after being tortured by the Vians. (TOS: "The Empath")

In 2369, Captain Jean-Luc Picard briefly died from internal hemorrhaging, as well as liver and spleen damage following an attack by Lenarians. (TNG: "Tapestry")

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