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Starbase 10 was a Federation starbase that was administered by Starfleet. The base was located near Deneva. A direct course from Gamma Hydra to this base would pass through the Romulan Neutral Zone. This star fell into the administrative area of the base.

In 2267, the USS Enterprise traveled to this base following its mission to Deneva. Later that year, Commodore Stocker was assigned command of the base and was transported there by the Enterprise. (TOS: "Operation -- Annihilate!", "The Deadly Years"; VOY: "Tinker Tenor Doctor Spy")

This base was also mentioned in gaming reference books (The Triangle Campaign, Starfleet Operations Manual), novels (Pocket TNG: Red Sector), and comics (Gold Key TOS: "Sceptre of the Sun" and Peter Pan Records: "The Robot Masters").
According to Star Trek: Star Charts (p. 66, "United Federation of Planets I") and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), Starbase 10 was located in the Beta Quadrant.

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