Starbase 22 was a Federation starbase administered by Starfleet. This base was located in the Beta Quadrant.

During the first Federation-Klingon War, on stardate 4851.5, a cloaked Klingon raider, on a suicide mission, tailed the USS Saratoga into spacedock at this base, where it ignited its antimatter supply. The subsequent explosion destroyed most of the ships docked there. This assault, along with two other similar assaults at Starbase 12 and Starbase 19, resulted in the destruction of one-third of Starfleet's ships. (DIS: "The War Without, The War Within")

In 2399, the location of Starbase 22 was labeled on a star chart that was in Fleet Admiral Kirsten Clancy's office at Starfleet Headquarters. (PIC: "Maps and Legends")


In the novel Ex Machina, Starbase 22 (β) had been rebuilt by 2273 and was the first stop of the USS Enterprise following her encounter with V'ger.

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