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Starbase 257 was a Federation Starbase 375-type starbase that was in service with Starfleet in the late 24th century. While within its defense perimeter, ships had to remain at one-half impulse until they cleared the outer markers.

In 2374, the starbase was attacked by an attack wing of Jem'Hadar fighters, shortly after the runabout USS Shenandoah had left the station en route to Ferenginar. (DS9: "Valiant")

According to Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), Starbase 257 was located in the Alpha Quadrant.

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