This page contains information regarding Star Trek: Discovery, and thus may contain spoilers.
The starbase was operational by at least 2256. (DIS: "Choose Your Pain") In that year, this starbase's location was labeled on the star chart "Alpha/Beta Quadrant Overview" in the ready room aboard the USS Discovery. (DIS: "Magic to Make the Sanest Man Go Mad")
In 2366, the USS Enterprise-D was diverted to the starbase to transport urgently needed medical supplies to the Alpha Leonis system, postponing its rendezvous with the USS Goddard. Several Enterprise crewmembers took extended shore leave here during this transport, as it was expected to be a quiet mission. (TNG: "The Vengeance Factor")