Starbase 74 was a Federation Spacedock-type starbase that was in service with Starfleet in the mid-24th century. This starbase orbited the planet Tarsas III. The starbase worked in conjunction with Starfleet Operational Support Services in the routine maintenance and upgrade of systems aboard starships. In 2364, the base was commanded by Commander Orfil Quinteros.
In that year, the USS Enterprise-D docked at Starbase 74 to undergo an upgrade to its computer systems, which was performed by a group of Bynars. The Enterprise was hijacked by the Bynars shortly after the upgrade began, and taken to Bynaus. The USS Melbourne was one of the three other starships docked at the time, but was unable to pursue due to repairs in progress. (TNG: "11001001")