Starbase 80 was a Federation starbase.

In the 2380s, Starbase 80 had a less-than-desirable reputation among the crew of the USS Cerritos, to the point that many crew members cried out in shock when Dr. T'Ana suggested that Ensign Beckett Mariner go work on the starbase to "goof around" after Mariner accidentally knocked T'Ana's face into her nachos. (LD: "Terminal Provocations")

This starbase was only mentioned in dialogue.
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