Starbase 80 was a Federation starbase.

In the 2380s, Starbase 80 had a less than desirable reputation among the crew of the USS Cerritos, to the point that many crew members cried out in fear when Dr. T'Ana suggested that Ensign Beckett Mariner go work on the starbase to "goof around" after Mariner accidentally fell on top of her. (LD: "Terminal Provocations")

This starbase was only mentioned in dialogue.
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