A strain was a genetic variant or subtype of a microorganism.

In 2366, Paul Stubbs compared the nanite infestation of the computer core of the USS Enterprise-D to watching a strain the Leutscher virus reproduce. (TNG: "Evolution")

In a fantasy created by Barash's neural scanners on Alpha Onias III in 2367, William T. Riker was told he had been infected with a strain of Altarian encephalitis that had supposedly lain dormant within before becoming active sixteen years later. (TNG: "Future Imperfect")

In an imaginary scenario experienced by Kathryn Janeway in 2373, Janeway was informed by The Doctor that she had contracted a virulent form of the Vidiian phage that was spreading rapidly through her system. (VOY: "Coda")

In 2374, The Doctor claimed an injured Romulan's blood contained a strain of the Terothka virus as a ruse to get onto the bridge of the hijacked USS Prometheus. (VOY: "Message in a Bottle")

In 2375, The Doctor informed "Daimon Torrot" – in fact Seven of Nine, whose own personality had been suppressed by those she’d assimilated while a Borg drone – that "he" had contracted a nasty strain of the Ankaran flu. (VOY: "Infinite Regress")

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