A strike occurred when a group of employees refused to work because they had some complaint about the working conditions that their employer was apparently unwilling to correct. Such events were often organized by unions.
In Pennsylvania in 1902, an ancestor of Miles O'Brien, Sean O'Brien went on strike with a group of employees, refusing to open the mine until their demands were met.
In 2372, Rom led a strike of the employees of Quark's (including the waiters and dabo girls) calling themselves the Guild of Restaurant and Casino Employees. During the strike, Brunt had Quark beaten up by a pair of Nausicaans. (DS9: "Bar Association")