Synaptic failure was the loss of the synaptic functions of the brain.

Following an attack, Vedek Bareil suffered from a synaptic failure and was treated by Doctor Julian Bashir aboard Deep Space 9. He applied direct neuro-stimulation to the brainstem but the left temporal lobe was showing massive signs of synaptic failure. (DS9: "Life Support")

Due to Tom Paris' punishment on the planet Banea, he suffered from reactions to the memory engram transplanted into his brain. At the request of Captain Kathryn Janeway, the Banean doctor supported her desire to transport Paris aboard USS Voyager to prevent a general synaptic failure. (VOY: "Ex Post Facto")

Paris experienced in one of his flashbacks that twenty-five microliters of acetylcholine were not helping Ahni Jetal and she got a massive synaptic failure. (VOY: "Latent Image")

The Lokirrim Jaryn told The Doctor, while he possessed Seven of Nine, about the results of a viral weapon from their photonic enemies – a complete synaptic failure within days. (VOY: "Body and Soul")

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