In 2373, Captain Kathryn Janeway of the USS Voyager unknowingly offended a member of the Tak Tak by placing her hands on her hips (one of the worst Tak Tak insults). Neelix worked very hard to deal with the situation and was, as a result, promoted to the unofficial position of ambassador. According to Janeway, not only were they "the most unforgiving people I've ever met", but they also "make the Klingons look sedate."
The Tak Tak had no cure for the macrovirus and had a policy of "purifying" any infected ship or colony. They destroyed an infected Garan mining colony in 2373 and also targeted Voyager for the same reasons. They called off their attack after Captain Janeway told them they had developed an antigen for the virus. (VOY: "Macrocosm")
Several Tak Tak were doing business on the space station close to the Nekrit Expanse. (VOY: "Fair Trade") It was a Tak Tak who provided the Voth scientist Gegen with a canister of Voyager's warp plasma. (VOY: "Distant Origin")
- No Tak Tak characters were ever assigned names in canon productions.