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The terminal stage of a disease was the point at which death became unavoidable and imminent.

In 2270, Leonard McCoy urged Spock to work harder to locate a cure for ill members of USS Enterprise's crew, as their condition was reaching the terminal stage. (TAS: "Albatross")

In 2375, Dr. Julian Bashir displayed two images of a Boranis III inhabitant before and after she had reached the terminal stage of the Teplan blight. He noted that necrotic lesion formation and an increase in leukocyte production were further markers of impending death. (DS9: "Inter Arma Enim Silent Leges")

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